Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(4)


Article History
Submitted: 11 Jul 2014
Revised: 03 Aug 2014
First published online: 31 Oct 2014

Article Access Statistics
Abstract Page Views: 324
PDF Downloads: 177
Full Text Views: 0

Adv Pharm Bull. 2014;4(6):549-554 doi: 10.5681/apb.2014.081
PMID:25671188        PMCID:PMC4312404

Formulation of Gammaoryzanol-Loaded Nanoparticles for Potential Application in Fortifying Food Products

Original Research

Serveh Ghaderi 1, Saeed Ghanbarzadeh 2, Zahra Mohammadhassani 3, Hamed Hamishehkar 4 *

1 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Student Research Committee, and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract
Purpose: The field of nanoparticle delivery systems for nutrients and nutraceuticals with poor water solubility has attracted a great attention during the last decades. Methods: Ethyl cellulose (EC) based GO-loaded nanoparticles were prepared by solvent evaporation method. The effects of formulation parameters on nanoparticle size, encapsulation efficiency (EE%) and loading efficiency (LE%) were investigated. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) techniques were used to investigate the crystalline behavior of GO and EC after the preparation of nanoparticles. Stability of the prepared nanoparticle was investigated during five weeks of storage. Results: Particle sizes of all formulation were in the range of 70-100 nm with narrow size distribution. Increase in the time of sonication from 1 to 5 minutes decreased the particle size. However, the mean particle size was increased when the sonication time increased from 5 to 7 minutes. The results showed that in the same concentration of PVA, increasing the ratio of EC:GO led to an increase in the GO encapsulation efficiency and decrease in loading efficiency. During five weeks, the mean diameter and size distribution indexes (SPAN values) of nanoparticles did not show significant changes. DSC and XRD studies indicated that crystallinity of GO was decreased in nanoparticles. Conclusion: EC based nanoparticles are promising carriers for addition of GO as a water insoluble antioxidant to fortify liquid food products without any change in quality of products.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Ghaderi S
Articles by Ghanbarzadeh S
Articles by Mohammadhassani Z
Articles by Hamishehkar H

PubMed
Articles by Ghaderi S
Articles by Ghanbarzadeh S
Articles by Mohammadhassani Z
Articles by Hamishehkar H

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN