Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Export citation
Reference Manager

Cite by
Google Scholar

Article History
Submitted: 31 Jan 2016
Revised: 04 May 2016
Accepted: 14 May 2016
First published online: 29 Jun 2016

Article Access Statistics
Abstract Page Views: 408
PDF Downloads: 293
Full Text Views: 0

Adv Pharm Bull. 2016;6(2):235-241 doi: 10.15171/apb.2016.032

Formulation and Physicochemical Characterization of Lycopene-Loaded Solid Lipid Nanoparticles

Research Article

Elham Nazemiyeh 1, Morteza Eskandani 2, Hossein Sheikhloie 1, Hossein Nazemiyeh 2,3 *

1 Department of Food Engineering, Maragheh Branch, Islamic Azad University, Maragheh, Iran.
2 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.


Purpose: Lycopene belongs to the carotenoids that shows good pharmacological properties including antioxidant, anti-inflammatory and anticancer. However, as a result of very low aqueous solubility, it has a limited systemic absorption, following oral administration.

Methods: Here, we prepared a stable lycopene-loaded solid lipid nanoparticles using Precirol® ATO5, Compritol 888 ATO and myristic acid by hot homogenization method with some modification. The size and morphological characteristics of nanoparticles were evaluated using Scanning Electron Microscopy (SEM). Moreover, zeta potential and dispersity index (DI) were measured using zeta sizer. In addition, encapsulation efficiency (EE%), drug loading (DL) and cumulative drug release were quantified.

Results: The results showed that the size and DI of particles was generally smaller in the case of SLNs prepared with precirol when compared to SLNs prepared with compritol. Scanning electron microscopy (SEM) and particle size analyses showed spherical SLNs (125 ± 3.89 nm), monodispersed distribution, and zeta potential of −10.06 ± 0.08 mV. High EE (98.4 ± 0.5 %) and DL (44.8 ± 0.46 mg/g) were achieved in the case of nanoparticles prepared by precirol. The stability study of the lycopene-SLNs in aqueous medium (4 °C) was showed that after 2 months there is no significant differences seen in size and DI compared with the fresh formulation.

Conclusion: Conclusively, in this investigation we prepared a stable lycopene-SLNs with good physicochemical characteristic which candidate it for the future in vivo trials in nutraceutical industries.

×  Lycopene ×  Solid Lipid Nanoparticles (SLNs) ×  Myristic acid ×  Hot homogenization method ×  Physicochemical characterization

First name  
Last name  
Email address  
Security code

This Article

Google Scholar
Articles by Nazemiyeh E
Articles by Eskandani M
Articles by Sheikhloie H
Articles by Nazemiyeh H

Articles by Nazemiyeh E
Articles by Eskandani M
Articles by Sheikhloie H
Articles by Nazemiyeh H

Share this article!

Press Manuscript Online. Powered by MAADRAYAN