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Advanced Pharmaceutical Bulletin
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Article History
Submitted: 21 Nov 2014
Revised: 18 Jun 2015
Accepted: 30 Jul 2015
First published online: 30 Nov 2015

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Adv Pharm Bull. 2015;5(4):531-536 doi: 10.15171/apb.2015.072
PMID:26819926        PMCID:PMC4729355

Anti-Inflammatory Effect of Taurine in Burned Patients

Original Research

Sima Lak 1, Alireza Ostadrahimi 2 * , Behrooz Nagili 1, Mohammad Asghari-Jafarabadi 3, Sanaz Beigzali 4, Feridoon Salehi 5, Roxana Djafarzadeh 6

1 Infectious and Tropical Disease Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Nutrition Research Center, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Road Traffic Injury Prevention Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Burn Center, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Scientific Associate, Global eLearning Academy, Geneva, Switzerland.



Abstract

Purpose: Burn induced inflammatory response can be mediated by reactive oxygen metabolites and accompanied by multiple organ dysfunction. Taurine has protective effects against various inflammatory conditions. The aim of this study was to determine the effect of Taurine supplement in thermal burn victims.

Methods: Thirty patients with severe thermal burns were enrolled in this randomized double-blinded clinical trial. These patients were randomly divided into two equal groups (namely Control and Taurine groups), where both received isocaloric and isonitrogenous formula. One group was supplemented with 50 mg/kg of Taurine per day for a duration of 10 days. Blood samples were obtained to measure Interleukin-10 (IL-10), high-sensitivity C-reactive protein (hs-CRP), and Tumor Necrosis Factor alpha (TNF-α) levels at the beginning and the end of the study.

Results: Change in serum level of IL-10 in Taurine group was more than Control group [-13.60(-31.40, -10.40) compared to -4.00(-20.00, -0.20) respectively; P = 0.030]. This change was significant in patients with more than 30% TBSA of burn [-14.20(-31.40, -10.40) compared to -2.40(-9.60, 0.40) respectively; P = 0.013]. As for the hs-CRP and TNF-α levels, the difference between the two groups were not significant.

Conclusion: Based on the results obtained, Taurine supplement showed a positive outcome on anti-inflammatory cytokine IL-10 in all burn patients. This effect was even more significant in patients with higher percentage of burn area. Taurine had no significant effect on the inflammatory marker hs-CRP and the pro-inflammatory cytokine TNF-α level. For a more thorough verification, measurement of a wider range of inflammatory cytokines in more frequent time intervals are suggested.







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Articles by Lak S
Articles by Ostadrahimi A
Articles by Nagili B
Articles by Asghari-Jafarabadi M
Articles by Beigzali S
Articles by Salehi F
Articles by Djafarzadeh R

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Articles by Lak S
Articles by Ostadrahimi A
Articles by Nagili B
Articles by Asghari-Jafarabadi M
Articles by Beigzali S
Articles by Salehi F
Articles by Djafarzadeh R

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