Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 16 Oct 2014
Revised: 25 Sep 2014
First published online: 19 Sep 2015

Article Access Statistics
Abstract Page Views: 264
PDF Downloads: 121
Full Text Views: 0

Adv Pharm Bull. 2015;5(3):343-349 doi: 10.15171/apb.2015.048
PMID:26504756        PMCID:PMC4616900

Formation and Characterization of Beclomethasone Dipropionate Nanoparticles Using Rapid Expansion of Supercritical Solution

Original Research

Mohsen Hosseinpour 1, Alireza Vatanara 2 * , Reza Zarghami 1

1 Pharmaceutical Engineering Laboratory, Multiphase Processes Department, School of Chemical Engineering, University of Tehran, Tehran, Iran.
2 Aerosol Research Laboratory, Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran.



Abstract

Purpose: Particle size of Beclometasone Dipropionate (BDP) was reduced by the rapid expansion of supercritical solution (RESS) process, using CO2 as supercritical solvent. Also, the effect of RESS parameters such as extraction pressure, pre-expansion temperature, and weight fraction of co-solvent on the size and distribution of BDP particles were investigated.

Methods: The effects of extraction pressure (200-260 bar), pre-expansion temperature (70-110 °C) and weight fraction of menthol as a co-solvent on mean particle size (MPS) of BDP were investigated by design of experiment (DOE). Particles were characterized using Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS).

Results: The average sizes of precipitated BDP were between 64.1 and 294 nm. Analysis of variance (ANOVA) showed that extraction pressure was the most significant parameter and a higher extraction pressure caused production of smaller particles. Also, it was found that higher temperature and weight fraction of co-solvent increased the MPS. The interaction effects of extraction pressure-pre-expansion temperature and pre-expansion temperature-co-solvent ratio were significant through the analysis of variance. It was observed that the MPS of precipitated particles was mostly influenced by pressure.

Conclusion: The smallest MPS of BDP obtained from the RESS process was 65 nm that revealed a significant size reduction from its original MPS of 9 μm. Moreover, a slight change was observed for precipitated particles of BDP into spherical form while the original particles were irregular in shape. RESS process showed as a promising method for production of BDP nanoparticles that may results in improvement of drug’s physicochemical properties.







Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Hosseinpour M
Articles by Vatanara A
Articles by Zarghami R

PubMed
Articles by Hosseinpour M
Articles by Vatanara A
Articles by Zarghami R

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN