Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(2)


Article History
Submitted: 20 Sep 2014
Revised: 16 Dec 2014
First published online: 05 Mar 2015

Article Access Statistics
Abstract Page Views: 319
PDF Downloads: 176
Full Text Views: 0

Adv Pharm Bull. 2015;5(1):25-33 doi: 10.5681/apb.2015.004
PMID:25789216        PMCID:PMC4352220

Lipid Vesicles for the Skin Delivery of Diclofenac: Cerosomes vs.  Other Lipid Suspensions

Original Research

Anahita Fathi-Azarbayjani 1,2 * , Kai Xin Ng 1, Yew Weng Chan 3, Sui Yung Chan 1

1 Department of Pharmacy, National University of Singapore, Block S4, level 2, Science Drive 4, 117543, Singapore.
2 Departent of Pharmaceutics, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
3 Department of Anaesthesiology, Singapore General Hospital, 169608, Singapore.



Abstract
Purpose: Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated and compared. Methods: Lipid vesicles were formulated and assessed with regards to enhancement of skin permeation of diclofenac and stability profiles of the formulations. Formulation-induced changes of the biophysical structure of excised human skin were monitored using the Fourier transform infrared spectroscopy. Results: The stability profiles of these suspensions over 12 weeks did not show any significant drug leakage from the vesicles of interest (p > 0.05). FTIR observations indicated that the vesicles increased stratum corneum (SC) lipid fluidization and altered protein conformation. Skin permeability experiments showed that the free unencapsulated drug in the cerosomal formulations caused significant increase in drug permeation across the skin (p < 0.01). Low skin permeability of drug from the other lipid suspensions could be due to the entrapment of diclofenac within these vesicles which decreased the solubility of the hydrophilic drug in the skin lipids and the partition coefficient of the drug from these vesicles into the SC. Conclusion: Optimal drug entrapment in vesicles or alteration of the skin structure may not necessarily enhance the permeation of hydrophilic drugs across the human skin. These lipid vesicles may be further developed into carriers of both hydrophilic and hydrophobic drugs for topical and transdermal delivery, respectively.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Fathi-Azarbayjani A
Articles by Ng KX
Articles by Chan YW
Articles by Chan SY

PubMed
Articles by Fathi-Azarbayjani A
Articles by Ng KX
Articles by Chan YW
Articles by Chan SY

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN