Purpose: In the present study the incompatibility of FLM (fluvoxamine)
with lactose in solid state mixtures was investigated. The compatibility was evaluated using different
physicochemical methods such as differential scanning calorimetry (DSC),
Fourier-transform infrared (FTIR) spectroscopy and mass spectrometry.
Methods: Non-Isothermally stressed physical mixtures were used to
calculate the solid–state kinetic parameters. Different thermal models such as
Friedman, Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) were used for
the characterization of the drug-excipient interaction.
Results: Overall, the incompatibility of FLM with lactose as a
reducing carbohydrate was successfully evaluated and the activation energy of
this interaction was calculated.
Conclusion: In this research the lactose and FLM Maillard
interaction was proved using physicochemical techniques including DSC and
FTIR. It was shown that DSC- based kinetic analysis provides fast and versatile kinetic comparison of
Arrhenius activation energies for different pharmaceutical samples.