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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 01 Feb 2016
Revised: 03 Dec 2016
Accepted: 08 Dec 2016
First published online: 13 Apr 2017

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Adv Pharm Bull. 2017;7(1):43-51 doi: 10.15171/apb.2017.006

Thermal Stability and Kinetic Study of Fluvoxamine Stability in Binary Samples with Lactose

Research Article

Faranak Ghaderi 1,2, Mahboob Nemati 1,3, Mohammad Reza Siahi-Shadbad 3,4, Hadi Valizadeh 5, Farnaz Monajjemzadeh 3,4 *

1 Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Drug and Food Control, Urmia University of Medical Sciences, Urmia, Iran.
3 Department of Drug and Food Control, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Department of Pharmaceutics, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract

Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in solid state mixtures was investigated. The compatibility was evaluated using different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR) spectroscopy and mass spectrometry.

Methods: Non-Isothermally stressed physical mixtures were used to calculate the solid–state kinetic parameters. Different thermal models such as Friedman, Flynn–Wall–Ozawa (FWO) and Kissinger–Akahira–Sunose (KAS) were used for the characterization of the drug-excipient interaction.

Results: Overall, the incompatibility of FLM with lactose as a reducing carbohydrate was successfully evaluated and the activation energy of this interaction was calculated.

Conclusion: In this research the lactose and FLM Maillard interaction was proved using physicochemical techniques including DSC and FTIR. It was shown that DSC- based kinetic analysis provides fast and versatile kinetic comparison of Arrhenius activation energies for different pharmaceutical samples.







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Articles by Ghaderi F
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