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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 27 May 2014
Revised: 27 Aug 2014
First published online: 31 Oct 2014

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Adv Pharm Bull. 2014;4(6):479-481 doi: 10.5681/apb.2014.071
PMID:25671178        PMCID:PMC4312394

Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages

Editorial

Sheida Shaafi, Javad Mahmoudi, Ali Pashapour, Mehdi Farhoudi, Saeed Sadigh-eteghad, Hossein Akbari *

1 Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract
Ischemic stroke is a leading cause of death and disability in the world. Many mechanisms contribute in cell death in ischemic stroke. Ketogenic diet which has been successfully used in the drug-resistant epilepsy has been shown to be effective in many other neurologic disorders. The mechanisms underlying of its effects are not well studied, but it seems that its neuroprotective ability is mediated at least through alleviation of excitotoxicity, oxidative stress and apoptosis events. On the basis of these mechanisms, it is postulated that ketogenic diet could provide benefits to treatment of cerebral ischemic injuries.





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