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Advanced Pharmaceutical Bulletin
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Article History
Submitted: 18 May 2014
Revised: 29 May 2014
First published online: 05 Mar 2015

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Adv Pharm Bull. 2015;5(1):103-108 doi: 10.5681/apb.2015.014
PMID:25789226        PMCID:PMC4352211

Effect of Taurine on Febrile Episodes in Acute Lymphoblastic Leukemia

Original Research

Mina Islambulchilar 1, Iraj Asvadi 2, Zohreh Sanaat 2, Ali Esfahani 2, Mohammadreza Sattari 2,3,4 *

1 Students' Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

* Corresponding Author: Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. E-mail: mrgsuk@yahoo.com



Abstract
Purpose: The purpose of our study was to evaluate the effect of oral taurine on the incidence of febrile episodes during chemotherapy in young adults with acute lymphoblastic leukemia. Methods: Forty young adults with acute lymphoblastic leukemia, at the beginning of maintenance course of their chemotherapy, were eligible for this study. The study population was randomized in a double blind manner to receive either taurine or placebo (2 gram per day orally). Life quality and side effects including febrile episodes were assessed using questionnaire. Data were analyzed using Pearson’s Chi square test. Results: Of total forty participants, 43.8% were female and 56.3 % were male. The mean age was 19.16±1.95 years (ranges: 16-23 years). The results indicated that the levels of white blood cells are significantly (P<0.05) increased in taurine treated group. There was no elevation in blasts count. A total of 70 febrile episodes were observed during study, febrile episodes were significantly (P<0.05) lower in taurine patients in comparison to the control ones.Conclusion: The overall incidence of febrile episodes and infectious complications in acute lymphoblastic leukemia patients receiving taurine was lower than placebo group. Taurine’s ability to increase leukocyte count may result in lower febrile episodes.





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