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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 23 Apr 2014
Revised: 24 Jun 2014
First published online: 01 Jun 2015

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Adv Pharm Bull. 2015;5(2):189-194 doi: 10.15171/apb.2015.026
PMID:26236656        PMCID:PMC4517078

Comparative Study on the Effects of Ceftriaxone and Monocytes on Recovery after Spinal Cord Injury in Rat

Original Research

Javad Tajkey 1, Alireza Biglari 2 * , Bohlol Habibi Asl 1 * , Ali Ramazani 3, Saeideh Mazloomzadeh 4

1 Department of Pharmacology, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
3 Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
4 Department of Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.



Abstract
Purpose: Comparison between the efficacy of ceftriaxone and monocytes on improvement of neuron protection and functional recovery after spinal cord injury (SCI) in rat. Methods: Rats were randomly divided into three groups of ten. Spinal cord injury was performed on rats under general anesthesia using the weight dropping method. Ceftriaxone was injected intraperitoneally 200 mg/kg/day for seven days after SCI. Monocytes were injected 2 × 105 cells 4 days after SCI. Hind limb motor function was assessed using the Basso, Beattie and Bresnahan (BBB) scale. Corticospinal tract (CST) axons were traced by injection of biotin dextran amine (BDA) into the sensorimotor cortex. Results: There were statistically significant differences in BBB scores in ceftriaxone in comparison to both monocytes receiving and control groups. On the other hand there were statistically significant differences in axon counting in both ceftriaxone and monocytes receiving groups in comparison to control group. Conclusion: Our findings suggest that ceftriaxone improves functional recovery more effective than monocytes in rats after SCI. These results are from an experimental model and validation is required for further investigation.





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