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Adv Pharm Bull. 2014;4(6): 527-531.
doi: 10.5681/apb.2014.078
PMID: 25671185
PMCID: PMC4312401
Scopus ID: 84921964471
  Abstract View: 1933
  PDF Download: 1023

Original Research

Anticholinesterase and Antityrosinase Activities of Ten Piper Species from Malaysia

Wan Mohd Nuzul Hakimi Wan Salleh 1, Nur Athirah Hashim 1, Farediah Ahmad 2*, Khong Heng Yen 1

1 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.
2 School of Chemistry and Environmental Studies, Faculty of Applied Sciences, Universiti Teknologi MARA Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia.
*Corresponding Author: Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia., Email: farediah@kimia.fs.utm.my

Abstract

Purpose: The aim of this study was to investigate acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and antityrosinase activities of extracts from ten Piper species namely; P. caninum, P. lanatum, P. abbreviatum, P. aborescens, P. porphyrophyllum, P. erecticaule, P. ribesioides, P. miniatum, P. stylosum, and P. majusculum. Methods: Anticholinesterase and antityrosinase activities were evaluated against in vitro Ellman spectroscopy method and mushroom tyrosinase, respectively. Results: The EtOAc extract of P. erecticaule showed the highest AChE and BChE inhibitory with 22.9% and 70.9% inhibition, respectively. In antityrosinase activity, all extracts of P. porphyrophyllum showed the highest inhibitory effects against mushroom tyrosinase, compared to standard, kojic acid. Conclusion: This study showed that P. erecticaule and P. porphyrophyllum have potential AChE/BChE and tyrosinase inhibition activities. The respective extracts can be explored further for the development of novel lead as AChE/BChE and tyrosinase inhibitors in therapeutic management of Alzheimer’s disease.
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Submitted: 20 Apr 2014
Revision: 27 May 2014
ePublished: 31 Oct 2014
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