Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 13 Jan 2015
Revised: 28 Jun 2015
Accepted: 30 Jul 2015
First published online: 30 Nov 2015

Article Access Statistics
Abstract Page Views: 468
PDF Downloads: 201
Full Text Views: 0

Adv Pharm Bull. 2015;5(4):507-514 doi: 10.15171/apb.2015.069
PMID:26819923        PMCID:PMC4729356

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

Original Research

Akbar Aliasgharzadeh 1, Mohammad Khalili 2, Elham Mirtaheri 3, Bahram Pourghassem Gargari 3, Farnaz Tavakoli 1, Mahdieh Abbasalizad Farhangi 4, Hossein Babaei 5, Parvin Dehghan 6 *

1 Faculty of Medicine, Bone Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Neurosciences Research Center Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Biochemistry and Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Nutrition research center, Department of Food Science and Technology, Student Research committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract

Purpose: This trial was conducted to evaluate the effects of oligofructose-enriched inulin on some of cardiovascular disease risk factors in women with type 2 diabetes.

Methods: 52 females (25<BMI<35 kg/m2) with type 2 diabetes were randomly assigned to two groups. Participants received 10g/d oligofructose-enriched inulin (n=27) or 10g/d placebo (n=25) for 8 weeks. Fasting blood samples were taken to measure metabolic profiles, malondialdehyd and antioxidant enzymes at baseline and after the 8 weeks intervention. Paired, unpaired sample t-test and analysis of covariance were used to comparison of quantitative variables.

Results: After 8 weeks, in the oligofructose-enriched inulin group there was a significant increase in total antioxidant capacity (0.2 mmol/l, 20.0%) and a significant decrease in fasting plasma glucose (19.2 mg/dL, 9.4%) HbA1c (0.5%, 8.4%), total cholesterol (TC) (28.0 mg/dL, 14.1%), low-density lipoprotein cholesterol (LDL-c) (22.0 mg/dL, 21.7%), TC/HDL-c ratio (0.73, 20.7%), LDL-c/HDL-c ratio (0.55, 27.5%) and malondialdehyd (1.7 nmol/ml, 39.7%) compared to the placebo group. Changes in concentrations of triglycerides, high-density lipoprotein cholesterol (HDLc), superoxide dismutase, catalase and glutathione peroxidase were not significant in oligofructose-enriched inulin group compared to the placebo group.

Conclusion: Oligofructose-enriched inulin may improve glycemic indices, lipid profile, antioxidant status and malondialdehyd in women with type 2 diabetes.







Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Aliasgharzadeh A
Articles by Khalili M
Articles by Mirtaheri E
Articles by Pourghassem Gargari B
Articles by Tavakoli F
Articles by Abbasalizad Farhangi M
Articles by Babaei H
Articles by Dehghan P

PubMed
Articles by Aliasgharzadeh A
Articles by Khalili M
Articles by Mirtaheri E
Articles by Pourghassem Gargari B
Articles by Tavakoli F
Articles by Abbasalizad Farhangi M
Articles by Babaei H
Articles by Dehghan P

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN