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Advanced Pharmaceutical Bulletin
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Article History
Submitted: 03 Sep 2014
Revised: 09 Mar 2015
First published online: 19 Sep 2015

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Adv Pharm Bull. 2015;5(3):379-384 doi: 10.15171/apb.2015.052
PMID:26504760        PMCID:PMC4616892

Swim Training Improves HOMA-IR in Type 2 Diabetes Induced by High Fat Diet and Low Dose of Streptozotocin in Male Rats

Original Research

Rafigheh Ghiasi 1, Farhad Ghadiri Soufi 2, Mohammad hossein Somi 1, Gisou Mohaddes 3, Fariba Mirzaie Bavil 4, Roya Naderi 3, Mohammad Reza Alipour 1 *

1 Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar-Abbas, Iran.
3 Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract

Purpose: Insulin resistance plays a key role in the onset and development of type 2 diabetes mellitus (T2DM) and its complications. In this study, we evaluated the effect of swim training on insulin resistance in diabetic rats.

Methods: Forty male Wistar rats were randomly divided into four groups (n=10): sedentary control (Con), sedentary diabetic (Dia), swim trained control (Exe) and swim trained diabetic (Dia+Exe) rats. Diabetes was induced by high fat diet (HFD) and a low dose of streptozotocin (35 mg/kg, i.p). In trained groups, one week after the induction of diabetes, animals were subjected to swimming (60 min/5 days a week) for 10 weeks. At the end of training, fasting blood sugar (FBS), oral glucose tolerance test (OGTT), fasting/basal insulin, glycosylated hemoglobin (HbA1c) levels, insulin resistance index, homeostasis model assessment method (HOMA-IR), triglycerides (TG,) total cholesterol (TCh), and high density lipoprotein (HDL) levels in blood were measured.

Results: Swimming significantly improved OGTT (P<0.01) and HOMA-IR (P<0.01). Swim training also significantly decreased FBS (p<0.01), fasting/basal insulin (P<0.01), HbA1C (p<0.01), TG (P<0.05), and TCh (P<0.05) levels. It also significantly increased HDL (p<0.05) level.

Conclusion: Our findings indicate that swim training improved glycemic control and insulin sensitivity in type 2 diabetes caused by high fat diet in male rats.







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