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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 15 Apr 2014
Revised: 23 Jul 2014
First published online: 01 Jun 2015

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Adv Pharm Bull. 2015;5(2):231-236 doi: 10.15171/apb.2015.032
PMID:26236662        PMCID:PMC4517093

Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats

Original Research

Roya Naderi 1, Gisou Mohaddes 1 * , Mustafa Mohammadi 1 * , Rana Ghaznavi 1, Rafigheh Ghyasi 1, Amir Mansour Vatankhah 1

1 Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran.



Abstract
Purpose: Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin - induced diabetic rats.
Methods: 28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, diabetes and exercise + diabetes. Diabetes was induced by injection of streptozotocin in male rats. Rats in the trained groups were subjected to voluntary running wheel exercise for 6 weeks. At the end of six weeks blood and heart tissue samples were collected and used for determination of antioxidant enzymes (including SOD, GPX and CAT activities) and MDA level.
Results: Exercise significantly reduced MDA levels both in the heart tissue (p<0.01) and blood samples (p<0.05). In addition, exercise significantly increased SOD (p<0.05), GPX (p<0.001) and CAT (p<0.05) in the heart tissue. Voluntary exercise also significantly increased SOD (p<0.01), GPX (p<0.05) and CAT (p<0.001) in the blood.
Conclusion: Voluntary exercise diminishes the MDA level in blood and heart tissue of diabetic rats. It also accentuates activities of SOD, GPX and CAT. Therefore, it may be considered a useful tool for the reduction of oxidative stress in diabetes.






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