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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Submitted: 08 Feb 2014
Revised: 29 Apr 2014
First published online: 18 Sep 2014

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Adv Pharm Bull. 2014;4(6):515-520 doi: 10.5681/apb.2014.076
PMID:25671183        PMCID:PMC4312399

The Effect of Cinnamon Extract and Long-Term Aerobic Training on Heart Function, Biochemical Alterations and Lipid Profile Following Exhaustive Exercise in Male Rats

Original Research

reza Badalzadeh 1, Mehrnoosh Shaghaghi 2, mustafa Mohammadi 1 * , Ghramreza Dehghan 2, Zynab Mohammadi 3

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
3 Medical Science Supreme Programming Council, Ministry of Health, Treatment and Medical education, Tehran, Iran.

Purpose: Regular training is suggested to offer a host of benefits especially on cardiovascular system. In addition, medicinal plants can attenuate oxidative stress-mediated damages induced by stressor insults. In this study, we investigated the concomitant effect of cinnamon extract and long-term aerobic training on cardiac function, biochemical alterations and lipid profile following exhaustive exercise. Methods: Male Wistar rats (250-300 g) were divided into five groups depending on receiving regular training, cinnamon bark extraction, none or both of them, and then encountered with an exhausted exercise in last session. An 8-week endurance training program was designed with a progressive increase in training speed and time. Myocardial hemodynamics was monitored using a balloon-tipped catheter inserted into left ventricles. Blood samples were collected for analyzing biochemical markers, lipid profiles and lipid-peroxidation marker, malondealdehyde (MDA). Results: Trained animals showed an enhanced cardiac force and contractility similar to cinnamon-treated rats. Co-application of regular training and cinnamon had additive effect in cardiac hemodynamic (P<0.05). Both regular training and supplementation with cinnamon significantly decreased serum levels of total cholesterol, low-density lipoprotein (LDL), and increased high-density lipoprotein (HDL) level and HDL/LDL ratio as compared to control group (P<0.01). Furthermore, pre-treatment with cinnamon extract and/or regular training significantly reduced MDA level elevation induced by exhausted exercise (P<0.01). Conclusion: Long-term treatment of rats with cinnamon and regular training improved cardiac hemodynamic through an additive effect. The positive effects of cinnamon and regular training on cardiac function were associated with a reduced serum MDA level and an improved blood lipid profile.

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