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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 01 Feb 2014
Revised: 12 Apr 2014
First published online: 25 Aug 2014

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Adv Pharm Bull. 2014;4(5):413-420 doi: 10.5681/apb.2014.061
PMID:25364656        PMCID:PMC4213779

Oral Oncoprevention by Phytochemicals - A Systematic Review Disclosing the Therapeutic Dilemma


Sujana Mulk Bhavana 1 * , Chintamaneni Raja Lakshmi 1

1 Department of Oral Medicine and Radiology, Drs Sudha & Nageswararao Siddhartha, Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhrapradesh, India.

The aim of this article is to emphasize and focus on the preclinical and clinical update on phytochemicals and their role in prevention of oral carcinogenesis. Accordingly, the literature search was made following database: Embase, Medline, Science Citation index, NIH public access, pubmed and Cochrane Database of systematic reviews. Several internet websites were also searched to access publications from major phytochemical research sites and relevant information was obtained with regards to each plant chemical. The authors also spotted different list servers through, Stanford cancer research etc: The data base search was made from the inception to 1988 and updated till 2013. A systematic method was obtained for literature search and data collection was critiqued. 60 articles were searched, among which there were only 6 systematic reviews on phytochemicals regarding oral carcinogenesis. Additional articles were obtained on phytochemicals and their mechanism of action in other cancers, which were regarded as background material. The studies done by various authors on each phytochemical has been briefly emphasized.

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