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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Submitted: 04 May 2014
Revised: 09 Jul 2014
First published online: 01 Jun 2015

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Adv Pharm Bull. 2015;5(2):289-291 doi: 10.15171/apb.2015.040
PMID:26236670        PMCID:PMC4517090

Host-guest Inclusion Complexes between Mitiglinide and the NaturallyOccurring Cyclodextrins α, β, and γ: A Theoretical Approach

Short Communication

Khaldun Mohammad Al Azzam 1 * , Ermafatiha Muhammad 2

1 Pharmacy Program, Batterjee Medical College for Science and Technology (BMC), 21442 Jeddah, Kingdom of Saudi Arabia.
2 School of Chemical Sciences, Universiti Sains Malaysia (USM), 11800 Penang, Malaysia.

Purpose: The present study is aimed to study the host-guest inclusion complexation of the naturally occurring cyclodextrins (CDs), namely; (a-CD,b-CD, and g-CD) with mitiglinide (MIT). Methods: Host-guest inclusion complexation was simulated using semi-empirical PM3 method. Results: The obtained results clearly indicate that the complexes formed are energetically favored in the presence of y-CD (Ecomp = -17.884 kcal/mol) of the optimal configurations of (1:1) MIT/y-CD inclusion complexes. Moreover, the results obtained reveal that the formation of more stable MIT/y-CD complex compared to MIT/a-CD or MIT/b-CD complexes is primarily due to differences in intermolecular hydrogen bonding. Conclusion: The present theoretical results may be informative to scientists who are devoting themselves to developing effective methods for enhancing the drug solubility.

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