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Article History
Submitted: 06 Nov 2013
Revised: 09 Dec 2013
First published online: 07 Feb 2014

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Adv Pharm Bull. 2014;4(3):209-217 doi: 10.5681/apb.2014.031
PMID:24754003        PMCID:PMC3992955

The Prelude on Novel Receptor and Ligand Targets Involved in the Treatment of Diabetes Mellitus

Reviews

Venu Gopal Jonnalagadda 1 * , Allam Venkata Sita Ram Raju 2, Srinivas Pittala 3, Afsar Shaik 4, Nilakash Annaji Selkar 5

1 Shree Dhootapapeshwar Ayurvedic Research Foundation (SDARF), Panvel, Navi Mumbai-410206, Maharastra, India.
2 National Institute of Pharmaceutical Education and Research, Bala Nagar, Hyderabad, Andhra Pradhesh-500037, India.
3 CSIR-Institute of Genomics and Integrative Biology, Near Jubilee Hall, Mall Road, Delhi-110 007, India.
4 Gokula Krishna college of Pharmacy, Sullurpet - 524121, Nellore dist, A.P, India.
5 National Institute for Research in Reproductive Health, Parel, Mumbai-400012, Maharastra, India.



Abstract
Metabolic disorders are a group of disorders, due to the disruption of the normal metabolic process at a cellular level. Diabetes Mellitus and Tyrosinaemia are the majorly reported metabolic disorders. Among them, Diabetes Mellitus is a one of the leading metabolic syndrome, affecting 5 to 7 % of the population worldwide and mainly characterised by elevated levels of glucose and is associated with two types of physiological event disturbances such as impaired insulin secretion and insulin resistance. Up to now, various treatment strategies are like insulin, alphaglucosidase inhibitors, biguanides, incretins were being followed. Concurrently, various novel therapeutic strategies are required to advance the therapy of Diabetes mellitus. For the last few decades, there has been an extensive research in understanding the metabolic pathways involved in Diabetes Mellitus at the cellular level and having the profound knowledge on cell-growth, cell-cycle, and apoptosis at a molecular level provides new targets for the treatment of Diabetes Mellitus. Receptor signalling has been involved in these mechanisms, to translate the information coming from outside. To understand the various receptors involved in these pathways, we must have a sound knowledge on receptors and ligands involved in it. This review mainly summarises the receptors and ligands which are involved the Diabetes Mellitus. Finally, researchers have to develop the alternative chemical moieties that retain their affinity to receptors and efficacy. Diabetes Mellitus being a metabolic disorder due to the glucose surfeit, demands the need for regular exercise along with dietary changes.





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