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Article History
Submitted: 05 Jan 2014
Revised: 29 May 2014
First published online: 31 Oct 2014

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Adv Pharm Bull. 2014;4(6):533-541 doi: 10.5681/apb.2014.079
PMID:25671186        PMCID:PMC4312402

In vitro Anti-oxidant Activity and HPLC-DAD System Based Phenolic Content Analysis of Codiaeum variegatum Found in Bangladesh

Original Research

Nadia Saffoon 1, Riaz Uddin 1, Nusrat Subhan 2, Hemayet Hossain 3, Hasan Mahmud Reza 4, Md Ashraful Alam 4 *

1 Department of Pharmacy, Stamford University, Dhaka, Bangladesh.
2 School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia.
3 BCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.
4 Department of Pharmaceutical Sciences, North South University, Bangladesh.



Abstract
Purpose: This study evaluated the in vitro antioxidant potential of two varieties of Codiaeum variegatum leaves (spiral (CP) and royal like (BP)) extracts. Methods: The different antioxidant assays, including DPPH free radical scavenging, nitric oxide scavenging, hydrogen peroxide, reducing power, total antioxidant activity, protection of lipid peroxidation and RBC membrane stabilization activity, were studied. Moreover, high-performance liquid chromatography (HPLC) coupled with diode-array detection was used to identify and quantify the phenolic compounds in the royal like (BP) leaves extract. Results: Codiaeum variegatum extracts showed effective DPPH free radical scavenging, hydrogen peroxide radical scavenging and nitric oxide scavenging activity. However, reducing power of ferric ion was not significant compared to the standard antioxidant activity. In addition, Codiaeum variegatum extracts exhibited protection against lipid peroxidation. The total antioxidant activity was increased dose dependently when compared with standard drug ascorbic acid. (-)-Epicatechin, p-coumaric acid, rutin hydrate and ellagic acid were identified in the extract. Among the phenolic compounds, ellagic acid was abundantly present in the extract. Conclusion: Our investigation suggests that Codiaeum variegatum leaves contain high amount of phenolic compounds which may responsible for its biological activities in folkloric medicine.





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