Tabriz University of Medical Sciences About    Newsletter    Contact Us    Create Account    Log in  
Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
Services
Export citation
EndNote
Reference Manager
BibTeX
Medlars
Refworks
Mendeley

Cite by
Google Scholar
PMC(0)


Article History
Submitted: 07 Jan 2014
Revised: 19 Mar 2014
First published online: 10 Aug 2014

Article Access Statistics
Abstract Page Views: 294
PDF Downloads: 173
Full Text Views: 0

Adv Pharm Bull. 2014;4(4):405-411 doi: 10.5681/apb.2014.060
PMID:25436199        PMCID:PMC4137433

Stability Indicating Liquid Chromatographic Method for the Simultaneous Determination of Rosuvastatin and Ezetimibe in Pharmaceutical Formulations

Short Communication

Mathrusri Annapurna Mukthinuthalapati 1 * , Venkatesh Bukkapatnam 1, Sai Pavan Kumar Bandaru 1

1 Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam-530045, India.



Abstract
Purpose: A simple stability indicating reverse phase liquid chromatographic method was developed for the simultaneous determination of rosuvastatin and ezetimibe in pharmaceutical formulations. Methods: Best chromatographic response was achieved with C18 column (250 X 4.6 mm, 5μm) with photo diode array (PDA) detector. The mobile phase was composed of a mixture of sodium acetate buffer (pH 4.0) and acetonitrile (30:70, %v/v) with a flow rate of 1.2 mL/min. (UV detection at 254 nm). Rosuvastatin and ezetimibe were subjected to stress conditions of degradation and the method was validated as per ICH guidelines. Results: The method shows linearity over a concentration range of 0.5–250 μg/ml for both rosuvastatin (r2 = 0.9993) and ezetimibe (r2 = 0.9996). Both the drugs are highly sensitive towards alkaline conditions in comparison to other stress conditions. Conclusion: The proposed method can be successfully applied to perform long-term and accelerated stability studies for the simultaneous determination of rosuvastatin and ezetimibe in pharmaceutical formulations.





Comments
First name  
Last name  
Email address  
Comments  
Security code



This Article
PDF

Google Scholar
Articles by Mukthinuthalapati MA
Articles by Bukkapatnam V
Articles by Bandaru SP

PubMed
Articles by Mukthinuthalapati MA
Articles by Bukkapatnam V
Articles by Bandaru SP

Similar articles in PubMed

Share this article!

Press Manuscript Online. Powered by MAADRAYAN