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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 02 Feb 2016
Revised: 05 Jun 2016
Accepted: 12 Jun 2016
First published online: 25 Sep 2016

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Adv Pharm Bull. 2016;6(3):301-308 doi: 10.15171/apb.2016.042

An Overview on Novel Microbial Determination Methods in Pharmaceutical and Food Quality Control

Review Article

Mahboob Nemati 1,2, Aliasghar Hamidi 1, Solmaz Maleki Dizaj 1, Vahid Javaherzadeh 3, Farzaneh Lotfipour 1,2 *

1 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Food & Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Science and Research Branch, Islamic Azad University, Tabriz, Iran.



Abstract
Traditional microbiological methods tend to be labor-intensive and time-consuming. Rapid and novel methods in microbiological tests provide more sensitive, precise and reproducible results compared with conventional methods. In microbiology, the most rapid testing methods belong to the field of biotechnology such as PCR, ELISA, ATP bioluminescence and etc. Nevertheless impedance microbiology, biosensors and analytical procedures to determine microbial constituents are of significance. The present review article was conducted using internet databases and related scientific literatures and articles that provide information on developments in the rapid methods in microbiology. The main focus is on the application of rapid methods in microbial quality control of pharmaceutical products. Reviewed literature showed that rapid methods and automation in microbiology is an advanced area for studying and applying of improved methods in the early detection, and characterization of microorganisms and their products in food, pharmaceutical and cosmetic industrials as well as environmental monitoring and clinical applications. It can be concluded that rapid methods and automation in microbiology should continue as potent and efficient technologies to develop the novel tests to be performed in the future because of the ever-increasing concerns about the safety of food and pharmaceutical products. However the main issues to be considered are the scale up of developed methods and the regulatory requirements.





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