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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 30 Jul 2013
Revised: 29 Oct 2013
First published online: 23 Dec 2013

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Adv Pharm Bull. 2014;4(1):75-81 doi: 10.5681/apb.2014.012
PMID:24409413        PMCID:PMC3885373

Isolation and Antimicrobial and Antioxidant Evaluation of Bio-Active Compounds from Eriobotrya Japonica Stems

Original Research

Khaled Nabih Rashed 1 * , Monica Butnariu 2

1 Pharmacognosy Department, National Research Centre, Dokki, Giza, Egypt.
2 Chemistry and Vegetal Biochemistry, Banat's University of Agricultural Sciences and Veterinary Medicine from Timisoara, Calea Aradului, Timisoara 300645, Romania.



Abstract
Purpose: The present study was carried out to evaluate antimicrobial and antioxidant activities from Eriobotrya japonica stems as well investigation of its chemical composition. Methods: Methanol 80% extract of Eriobotrya japonica stems was tested for antimicrobial activity against bacterial and fungal strains and for antioxidant activity using oxygen radical absorbance capacity (ORAC) and the trolox equivalent antioxidant capacity (TEAC) assays and also total content of polyphenols with phytochemical analysis of the extract were determined. Results: The results showed that the extract has a significant antimicrobial activity, it inhibited significantly the growth of Candida albicans suggesting that it can be used in the treatment of fungal infections, and it showed no effect on the other bacterial and fungal strains, the extract has a good antioxidant activity, it has shown high values of oxygen radical absorbance capacity and trolox equivalent antioxidant capacity, while it showed a low value of polyphenol content. Phytochemical analysis of the extract showed the presence of carbohydrates, terpenes, tannins and flavonoids, further phytochemical analysis resulted in the isolation and identification of three triterpenic acids, oleanolic, ursolic and corosolic acids and four flavonoids, naringenin, quercetin, kaempferol 3-O-β-glucoside and quercetin 3-O-α-rhamnoside. Conclusion: These results may help to discover new chemical classes of natural antimicrobial antioxidant substances.





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