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Advanced Pharmaceutical Bulletin
ISSN: 2228-5881      eISSN: 2251-7308  
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Article History
Submitted: 12 Oct 2013
Revised: 16 Jan 2014
First published online: 07 Feb 2014

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Adv Pharm Bull. 2014;4(3):309-312 doi: 10.5681/apb.2014.045
PMID:24754017        PMCID:PMC3992969

Drug-Drug/Drug-Excipient Compatibility Studies on Curcumin using Non-Thermal Methods

Short Communication

Moorthi Chidambaram 1 * , Kathiresan Krishnasamy 1

1 Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India.



Abstract
Purpose: Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric. Clinical usefulness of curcumin in the treatment of cancer is limited due to poor aqueous solubility, hydrolytic degradation, metabolism, and poor oral bioavailability. To overcome these limitations, we proposed to fabricate curcumin-piperine, curcumin-quercetin and curcumin-silibinin loaded polymeric nanoformulation. However, unfavourable combinations of drug-drug and drug-excipient may result in interaction and rises the safety concern. Hence, the present study was aimed to assess the interaction of curcumin with excipients used in nanoformulations.Methods: Isothermal stress testing method was used to assess the compatibility of drug-drug/drug-excipient.Results: The combination of curcumin-piperine, curcumin-quercetin, curcumin-silibinin and the combination of other excipients with curcumin, piperine, quercetin and silibinin have not shown any significant physical and chemical instability.Conclusion: The study concludes that the curcumin, piperine, quercetin and silibinin is compatible with each other and with other excipients.





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